NEWS

A paper published in Advanced Materials Technologies, highlighting the potential of Electrokinetic Deterministic Lateral Displacement in sorting sub-micron particles

Researchers from Tegenfeldt group, Lund University, Sweden (Jason Beech, Bao Ho, Jonas Tegenfeldt) and Guiducci group, EPFL, Switzerland (Kevin Keim, Carlotta Guiducci) made a cover in the journal Advanced Materials Technologies with their novel metal-coated Electrokinetic Deterministic Lateral Displacement (Electrokinetic DLD) devices. These devices bring about several advantages: tuneable particle separations, significant reduction the critical size, and increase in the dynamic range with switching times on the order of seconds. Most notably, in a device having gap size of around 10 µm, polystyrene particles as small as 250 nm can be displaced, demonstrating two-orders of magnitude reduction in critical size using Electrokinetic DLD, as compared to conventional DLD.
https://doi.org/10.1002/admt.201900339

https://zenodo.org/record/3352780#.XZHEh1Uzapo

FET seminar on the evFOUNDRY

An evFOUNDRY presentation starred the FET seminar series on Thursday October 10th at the European Commission Covent Garden building (Brussels). The seminar was actively participated by a varied audience, including EU scientific project officers, economists and policy makers.
 

evFOUNDRY first Review Meeting in Brussels

On the 11th of October 2019 all members of evFOUNDRY Consortium met at Research Executive Agency in Brussels for the first Reporting Period Review Meeting.

Our project officer, Adriana Godeanu-Metz, chaired the meeting sessions.

All the activities conducted during in the different work packages have been presented and discussed with the reviewers.

The Aarhus group of evFOUNDRY participated in the 1st annual meeting in The Danish Society of Extracellular Vesicles (DSEV) held in Aarhus, Denmark.

On the 3rd of October 2019, the Aarhus group of evFOUNDRY participated in the 1st annual meeting in The Danish Society of Extracellular Vesicles (DSEV) held in Aarhus, Denmark. Peter Nejsum and Anne Borup are on the board and founders of the society and were responsible for organizing the event. Anne presented a poster of results related to evFOUNDRY (see picture).

evFOUNDRY took part at the MEETmeTONIGHT (European Researchers’ Night) and Future Tech Week events.

On September 27th evFOUNDRY took part at the MEETmeTONIGHT (European Researchers’ Night) and Future Tech Week  events.

CSGI members introduced students, kids and general public to evFOUNDRY aims and strategies with a ludic-scientific stand. Venue of the event has been Santa Giulia museum in Brescia, Italy.

http://www.meetmetonight.it/

http://futuretechweek.fetfx.eu/

Debora Berti, member of the CSGI team has been appointed in the Scientific Advisory Board for SweDeliver

Debora Berti has been appointed as SAB member for Swedish Drug Delivery Center for the period 2020-2024 with a budget of 3M Euro.

https://www.vinnova.se/en/news/2019/06/efforts-on-world-class-research-environments/

evFOUNDRY M12 meeting in Bologna (Italy)

On September 5-6 2019, the evFOUNDRY team met in Bologna (hosted by ISMN – CNR  - www.ismn.cnr.it) to review the first 12 months of activity and plan next moves also in the perspective of the review meeting that will be held in Bruxelles in October. The meeting saw the participation of researchers from each partner of the evFOUNDRY consortium (see picture) involved in two days of intense discussion.

Workshop on CONAN assay in Brescia (Italy)

On the 4th of September, a workshop was held in Brescia, Italy for members of the evFOUNDRY project. Bao Dang Ho (Lund, Sweden) and Francesca Loria (Estonia, Hansa-Biomed) attended a theoretical and practical course on Colorimetric Nanoplasmonic (CONAN) assay developed in Paolo Bergese’s lab.

On the picture, from the left: Lucia Paolini, Bao Dang Ho and Francesca Loria.

evFOUNDRY got to Singapore

On 30 July 2019 Paolo Bergese introduced evFOUNDRY at the National University of Singapore (NUS), while giving a research seminar on "Nanotechnology of Cell Communication". The seminar was hosted by Prof. Rachel Ee (Dep. of Pharmacy, Faculty od Science) and Prof. James Kah (Dep. of Biomedical Engineering, Faculty of Engineering).

http://www.ee-research-group.com/

http://bioeng.nus.edu.sg/nnl/

On Nature Nanotechnology Paolo Bergese comments with other bio-nano experts on transparency and reproducibility in nanomedicine

Joy Wolfram, Sara Busatto, Mauro Ferrari and Paolo Bergese contributed, together with other international bio-nano experts, to comment the paper "Minimum information reporting in bio–nano experimental literature - MIRIBEL" . The correpondence is now published by Nature Nanotechnology. Their piece advocates integrating MIRIBEL (which is focused on synthetic nanoparticles) with specific considerations related to biogenic nanoparticles such as extracellular vesicles.

https://www.nature.com/articles/s41565-019-0496-9

https://www.nature.com/articles/s41565-018-0246-4

evFOUNDRY at XLVII National meeting of the Physical Chemistry Division of the Italian Chemistry Society, Rome 1-4 July 2019

evFoundry members attended the XLVII National meeting of the Physical Chemistry Division of the Italian Chemistry Society (Physics Department, "Sapienza" University of Rome, 1-4 July 2019) with several contributions:

Costanza Montis with a talk entitled "Interaction of inorganic nanoparticles with synthetic and biogenic lipid membranes: fundamental understanding and biomedical applications'"

Andrea Ridolfi with a poster: "Nanomechanical classification of extracellular vesicles" (see figure)

Debora Berti with a talk entitled  "Nanostructured materials interacting with synthetic and natural lipid mesophases: challenges and opportunities"

See the meeting website for more details: http://congressodcf2019.it/english/

Costanza Montis (evFOUNDRY personnel, CSGI) selected for a presentation in Young investigator perspective section at 9th International Colloids Conference

Costanza Montis gave a talk entitled "Interaction of inorganic nanoparticles with synthetic and biogenic lipid membranes: fundamental understanding and biomedical applications" in the Young Investigator Perspective section at the 9th International Colloids Conference, Sitges (Barcellona, Spain), June 16-19 2019. 

See the meeting website for more details: https://www.elsevier.com/events/conferences/international-colloids-conference

Workshop milk EV isolation at Utrecht University

From May 27 to May 29, Utrecht University was the stage for a workshop of milk EV isolation. In the group of Marca Wauben, visitors Richard Gillams (Southampton, UK) and Bao Dang Ho (Lund, Sweden) experienced first-handedly what its like to process raw cow's milk and to prepare size exclusion columns and density gradients needed for further purification of milk EVs.
 
Congratulations Ric and Bao, for your first batch of purified milk EVs!

ISEV Special Achievement Award 2019 - Recipient: Marca Wauben for recognition of her extraordinary service to EV science and to ISEV

The International Society for Extracellular Vesicles (ISEV) is pleased to announce two Special Achievement Awards that were presented at the ISEV2019 annual meeting in Kyoto, Japan, 24–28 April 2019. ISEV Special Achievement Awards are given each year to one or more individuals who have made outstanding contributions to the field of extra- cellular vesicle (EV) research or have performed extraor- dinary service to ISEV. In 2019, ISEV Special Achievement Awards were presented to Professors Takahiro Ochiya, PhD, and Marca Wauben, PhD (see Figure)

https://www.isev.org/page/ISEVSpecialAchievementAward

https://www.tandfonline.com/doi/full/10.1080/20013078.2019.1620080

Workshop for evFOUNDRY-members in Aarhus (DK)

On the 24th of May, a workshop was held in Aarhus, Denmark for members of the evFOUNDRY. It was a full day of discussion and demonstration of how Peter Nejsum’s group isolate and characterize EVs from Ascaris Suum helminths. Richard Gillams (Southhampton, UK) and Bao Dang Ho (Lund, Sweden) participated.

On the picture, from the left Richard Gilliams, Anne Borup and Bao Dang Ho.

evFOUNDRY at ISEV annual meeting 2019 in Kyoto, Japan

evFOUNDRY will be at the annual meeting of the International Society of Extracellular Vesicles (ISEV) (Kyoto from 24th-28th April 2019), contributing to several sessions:

Martijn van Herwijnen (Utrecht University) will give a lecture on “Therapeutic Potential of Milk EVs” at the educational day (24th April)

Annalisa Radeghieri (CSGI) will give an oral presentation entitled “Different ATT isoforms are associated to EVs from ATT type II deficient patients” at the “EVs in Blood and Blood Disorders” session (25th April)

Lucia Paolini and Martijn van Herwijnen will present a poster on “The extracellular vesicle foundry: evFOUNDRY” at the “Network/society” session and will attend the ISEV Board (26th April)

Marca Wauben (Utrecht University, Secretary General of ISEV and part of the Organizing Committee of ISEV2019) will chair the “Plenary Session on RNA” (27th April).

Lucia Paolini will present two posters: “Fourier-transform Infrared Spectroscopy (FT-IR) to fingerprint EV subpopulations as a whole” and “Taxonomy of individual EVs by nanomechanics” at the “Advances in EV Quantification and Characterization” poster session (27th April). 

See the meeting program for more details: https://www.isev.org/page/ISEV2019

Lucia Paolini invited talk at the “Mini-Workshop on Extracellular Vesicles: from biophysical properties to therapeutic applications”

On Thursday April 11 Lucia Paolini (evFOUNDRY personnel, CSGI) gave an invited talk at the “Mini-Workshop on Extracellular Vesicles: from biophysical properties to therapeutic applications” within EXOTHERA project funded by Interreg Italia-Österreich programme. The talk presented “evFOUNDRY: the extracellular vesicle foundry” project (see flayer for details).

Anne Borup (involved in the evFOUNDRY) have recently received two awards

First, she was awarded ‘best poster presentation’ at the PhD day, 2019 at Aarhus University and secondly she was awarded the ‘young scientist award’ for best poster presentation at the Spring Symposium 2019 in Copenhagen hosted by the Danish Society for Parasitology.

evFOUNDRY M7 meeting in Lund

On March 27th-29th 2019, the evFOUNDRY team met in Lund (hosted by LINXS - Lund Institute of Advanced Neutron and X-ray Studies http://www.linxs.lu.se) to review the first 6 months of activity and plan next moves. The meeting saw for the first time the participation of all the involved young researchers (see picture, from the left Karolina Mothander (Sweden), Lucia Paolini (Italy), Richard Gillams (UK), Andrea Ridolfi (Italy), Anne Borup (Denmark), Anders T Boysen (Denmark), Costanza Montis (Italy), Francesca Loria (Estonia), Bao Dang Ho (Sweden), Martijn van Herwijnen (The Netherlands) not in the picture).
 

Interview on milk Extracellular Vesicles by Martijn van Herwijnen (evFOUNDRY personnel)

The faculty of Veterinary Medicine from Utrecht University has released a new volume of VetScience magazine. This special issue on Future Food includes interviews with Professor of Intercellular Communication Marca Wauben and Martijn van Herwijnen, who explains about his work about milk-derived Extracellular Vesicles (in Dutch). http://www.uu.nl/sites/default/files/vetscience_nov2018.pdf

Ph.D. course: Extracellular vesicles (EVs) – an introduction

 Members of the Evfoundry consortium have taken the initiative, and for the first time, been running the 3 day long Ph.D. course 'Extracellular vesicles (EVs) – an introduction' at Aarhus University, Denmark, March 2019. There were 10 participants from different universities in Denmark. The participants were introduced to EVs and different aspects of EV biology and how to characterize and explore the function of EVs. During the laboratory exercises the participants enriched for EVs and characterized their sizes and numbers and finally, used western blots to identify specific markers of EVs.

Innovation hub on extracellular vesicles in Lombardy Region

evFOUNDRY will participate to a kick off event for establishing an innovation hub on extracellular vesicles in Lombardy Region. The meeting will be held on May 9th, 2019 in Milano (see flyer for details). 

Annalisa Radeghieri (evFOUNDRY personnel) receives funding for engineering extracellular vesicles to deliver antitumor agents to triple negative breast cancer organoids

Annalisa Radeghieri (evFOUNDRY personnel) has received 120,000 euro (approximately USD 137,000) in funding in the framework of an Italian Education and Research Ministry (MIUR-PRIN) grant. The project aims at “Development of biotechnological nanoparticle platform for the delivery of antitumor therapies using Patient Derived-Organoids library of Breast cancer”. It brings in collaboration University of Milano-Bicocca, University of Milan, National Research Council and University of Rome Tor Vergata. 

http://www.miur.gov.it/

Professor Peter Nejsum (evFOUNDRY personnel) receives million-funding for development of new treatment method.

Danish Professor Peter Nejsum (evFOUNDRY personnel) has received DKK 3 million (approximately USD 457,800) in funding for a project to develop a new method to diagnose and treat diseases. The aim is to discover new immunotherapies and diagnose cancer through blood tests. But first step on the journey goes to the local abattoir to collect a bucket of roundworm. 

https://medwatch.dk/secure/Top_picks_in_english/article11041255.ece

Processing large volumes of EV sources. First study supported by evFOUNDRY published on Cells.

Sara Busatto and Paolo Bergese (evFOUNDRY PI) co-authored with Joy Wolfram and colleagues from the Mayo Clinic and the Houston Methodist Research Institute a paper on the use of tangential flow filtration (TFF) for highly efficient concentration of nanosized EVs from large volumes of fluid. The study contributes to evFOUNDRY effort in exploring methods for robust massive separation of EVs based on size.
https://doi.org/10.3390/cells7120273

Debora Berti, member of the CSGI team has been appointed in the Editorial Board of Advances in Colloid and Interface Science.

Debora Berti, member of the CSGI team has been appointed in the Editorial Board of Advances in Colloid and Interface Science, an international journal devoted to experimental and theoretical developments in Interfacial and Colloidal Phenomena and their implications in Biology, Chemistry, Physics and Technology. https://www.journals.elsevier.com/advances-in-colloid-and-interface-science/editorial-board

MISEV2018 is online

Researchers involved in evFOUNDRY contributed to the last update of the “Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines”, which was published online in the Journal of Extracellular Vesicles at the beginning of this week. https://www.tandfonline.com/doi/full/10.1080/20013078.2018.1535750

evFOUNDRY researcher Lucia Paolini selected for FET2RIN business training

evFOUNDRY researcher Lucia Paolini was selected for the FET2RIN training course (three workshops from mid-December 2018 to mid-February 2019 in Brussels).
The training, in collaboration with META, European Crowdfunding Network (ECN), and European Business and Innovation Centre Network (EBN), will help to look at FET project from a business perspective, assessing its strengths and weaknesses on the route to commercialization (http://www.fet2rin.com/home).

KICK OFF PARTNERS’ MEETING

KICK OFF PARTNERS’ MEETING On September 12 2018, at Plesso di SANTA TERESA Florence, next to the workshop (https://www.quotidiano.net/blog/malpelo/ricerca-vescicole-extracellulari-come-taxi-per-farmaci-e-vaccini-33.2061 http://www.meetthelifesciences.it/it/archvio/831-nanotecnologie-evfoundry-nuovi-approcci-ed-utilizzi-delle-vescicole-extracellulari) it’s time for the partners meeting.

evFOUNDRY researchers participate in the foundation of EVITA, the Italian Society of Extracellular Vesicles

On October 5 2018, Lucia Paolini (evFOUNDRY recruited researcher) with Annalisa Radeghieri  (evFOUNDRY personnel, CSGI), Natasa Zarovni (evFOUNDRY personnel, HansaBioMed Life Sciences) and Paolo Bergese (evFOUNDRY coordinator) will participate in the foundation of the Italian Society of Extracellular Vesicles - EVITA.  The meeting will be held at CNR headquarters in Rome.  EVITA will connect leading Italian scientists from all the disciplines involved in EV research in the effort to advance EV research nationally and globally, in tight relationship with other EV Societies, including The International Society for Extracellular Vesicles (https://www.isev.org), the Spanish GEIVEX (http://geivex.org) and the American Society for Exosomes and Microvesicles (https://www.asemv.org).  

Annalisa Radeghieri invited talk at the International Conference on Bioengineering and Cell Therapy

On Friday September 21 Annalisa Radeghieri  (evFOUNDRY personnel, CSGI) will give an invited talk at the International Conference on Bioengineering and Cell Therapy.

The talk will be focused on the potentiality of extracellular vesicles in regenerative medicine. 

Kick off workshop

On September 12 2018, at Plesso di SANTA TERESA Florence , evFOUNDRY kicks off and opens to academic and non-academic communities with a free workshop on “Extracellular vesicles, a breakthrough in precision medicine and nanotechnology”, which sees the partners lecturing on their role and science in the project.

PRESS: quotidiano.net

Vescicole extracellulari come navette, consegnano farmaci e vaccini. https://www.quotidiano.net/blog/malpelo/ricerca-vescicole-extracellulari-come-taxi-per-farmaci-e-vaccini-33.2061 .

PRESS: Meet the Life Sciences

Nanotecnologie: nuovi approcci ed utilizzi delle vescicole extracellulari. http://www.meetthelifesciences.it/it/archvio/831-nanotecnologie-evfoundry-nuovi-approcci-ed-utilizzi-delle-vescicole-extracellulari