WEBSITE

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https://www.ecs.soton.ac.uk/centre-for-hybrid-biodevices#research
https://www.southampton.ac.uk/

AFFILIATION

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Ranked in the top one per cent of universities globally and among the UK's top 20 for research, the University of Southampton has an international reputation for its research, teaching and enterprise activities. The department of Electronics and Computer science is ranked first in the UK for the volume and quality of research in Electrical and Electronic Engineering.

RESEARCH ACTIVITY

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The Morgan research group has a long-standing interest in developing bioelectronic and microfluidic platforms. The incorporation of electronics into microfluidic systems has led to increases in the control of sample separation, facilitated remote biosensing and improved the study of biological samples in near-physiological conditions.
Research in the Attard group has focused on understanding complex systems. This has increased the understanding of the regulation and role of lipids in biological systems. By combining fundamental physical chemistry and lipidomics approaches, the group has identified and elucidated a pathway for the homeostatic control of lipid membrane composition.

evFOUNDRY PROJECT CONTRIBUTION

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Within the evFOUNDRY project, the Southampton team are working on developing microfluidic technologies for the effective separation and detection of extra-cellular vesicles from the samples provided by project partners in Aarhus and Utrecht. In addition a working prototype device will be produced in Southampton, which combines the technologies developed in Southampton, Lund and at the CSGI.

SELECTED PUBLICATIONS

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• Calero, V., Garcia-Sanchez, P., Honrado, C. M., Ramos, A. & Morgan, H. (2019) AC electrokinetic biased deterministic lateral displacement for tunable particle. Lab on a Chip, 19 (8), 1386-1396. (doi:10.1039/C8LC01416G).
• Calero, V., Garcia-Sanchez, P., Ramos, A. & Morgan, H. (2019) Combining DC and AC electric fields with Deterministic Lateral Displacement for Micro- and Nano-particle separation. Biomicrofluidics, 13. (doi:10.1063/1.5124475).
• Dymond, M. K., Gillams, R. J., Parker, D., Burrell, J., Labrador, A., Nylander, T., & Attard, G. (2016). Lipid spontaneous curvatures estimated from temperature-dependent changes in inverse hexagonal phase lattice parameters: effects of metal cations. Langmuir, 32(39), 10083-10092. DOI: 10.1021/acs.langmuir.6b03098
• Hunter, J. E., Brandsma, J., Dymond, M. K., Koster, G., Moore, C. M., Postle, A., Mills, R. A., & Attard, G. S. (2018). Lipidomics of Thalassiosira pseudonana under phosphorus stress reveal underlying phospholipid substitution dynamics and novel diglycosylceramide substitutes. Applied and Environmental Microbiology, 84(6), 1-17. [e02034-17]. DOI: 10.1128/AEM.02034-17