The group is part of Clinical Medicine at Aarhus University, and is based at the Department of Infectious Diseases at Aarhus University Hospital. The department has years of experience with the interplay between pathogens and the immune system, which is combined with a network branching beyond borders creating a great international expertise system and papers in high impact journals.
The group explore how products from parasitic worms (helminths) modulate the host immune response with a special focus on the role of extracellular vesicles (EVs). We search to determine the characteristics and role of EVs in the interplay between helminths and the host with the purpose of identifying novel therapeutics for autoimmune diseases and vaccines.
evFOUNDRY PROJECT CONTRIBUTION
For the evFOUNDRY, our group will isolate and enrich for EVs from the porcine helminth Ascaris suum in the most efficient and optimal way. We also explore the characteristics and physical properties of EVs. Finally, we investigate the functionality of helminth-derived EVs using in vitro studies. In this way we will identify the best method, called ‘gold standard’ for Ascaris EV enrichment and compare that to the performance of the evFOUNDRY.
- Hansen E.P., Fromm, B., Andersen, S.D., Marcilla, A., Andersen, K.L., Borup, A., Williams, A.R., Jex, A., Gasser, R.B., Young, N.D., Hall, R.S., Stensballe, A., Ovchinnikov, V., Yan, Y., Fredholm, M., Thamsborg, S.M., Nejsum, P. (2018). Exploration of extracellular vesicles from Ascaris suum provides evidence of parasite-host cross talk, submitted
- Zakeri, A., Hansen, E.P., Andersen, S.D., Williams, A.R., Nejsum, P. (2018). Immunomodulation by helminths: Intracellular pathways and extracellular vesicles. Frontiers in Immunology, 9:2349.
- Midttun, H.L.E., Acevedo, N., Skallerup, P., Almeida, S., Skovgaard, K., Andresen, L., Skov, S., Caraballo, L., van Die, I., Jørgensen, C.B., Fredholm, M., Thamsborg, S.M., Nejsum, P.,* Williams, A.R.* (2018). Ascaris suum infection down-regulates mucosal inflammatory pathways in pigs in vivo and in human dendritic cells in vitro. Journal of Infectious Diseases, 218: 310-319
* shared senior author
- Almeida, S., Nejsum, P., Williams, A.R. (2017). Modulation of human macrophage activity by Ascaris antigens is dependent on macrophage polarization state. Immunobiology, 223: 405-412
- Hansen E.P., Kringel H., Williams A.R., Nejsum, P. (2015). Secretion of RNA-containing extracellular vesicles by the porcine whipworm, Trichuris suis. Journal of Parasitology, 101:336-340
Telephone: +45 50541392
Dep. Of Clinical Medicine
Dep. Of Infectious Diseases, Q-Research
Palle Juul-Jensens Boulevard 99
8200 Aarhus N