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AARHUS UNIVERSITY
AARHUS UNIVERSITY

TEAM


Peter Nejsum

Professor MSO, PhD

Orcid: https://orcid.org/0000-0002-6673-8505

pn@clin.au.dk

WEBSITE


https://pure.au.dk/portal/en/persons/peter-nejsum(ee468e32-0a8b-4cd3-9473-60335cf27df9).html

AFFILIATION


The group is part of Clinical Medicine at Aarhus University, and is based at the Department of Infectious Diseases at Aarhus University Hospital. The department has years of experience with the interplay between pathogens and the immune system, which is combined with a network branching beyond borders creating a great international expertise system and papers in high impact journals.

RESEARCH ACTIVITY


The group explore how products from parasitic worms (helminths) modulate the host immune response with a special focus on the role of extracellular vesicles (EVs). We search to determine the characteristics and role of EVs in the interplay between helminths and the host with the purpose of identifying novel therapeutics for autoimmune diseases and vaccines.

evFOUNDRY PROJECT CONTRIBUTION


For the evFOUNDRY, our group will isolate and enrich for EVs from the porcine helminth Ascaris suum in the most efficient and optimal way. We also explore the characteristics and physical properties of EVs. Finally, we investigate the functionality of helminth-derived EVs using in vitro studies. In this way we will identify the best method, called ‘gold standard’ for Ascaris EV enrichment and compare that to the performance of the evFOUNDRY.

SELECTED PUBLICATIONS


  • Hansen E.P., Fromm, B., Andersen, S.D., Marcilla, A., Andersen, K.L., Borup, A., Williams, A.R., Jex, A., Gasser, R.B., Young, N.D., Hall, R.S., Stensballe, A., Ovchinnikov, V., Yan, Y., Fredholm, M., Thamsborg, S.M., Nejsum, P. (2018). Exploration of extracellular vesicles from Ascaris suum provides evidence of parasite-host cross talk, submitted
  • Zakeri, A., Hansen, E.P., Andersen, S.D., Williams, A.R., Nejsum, P. (2018). Immunomodulation by helminths: Intracellular pathways and extracellular vesicles. Frontiers in Immunology, 9:2349.
  • Midttun, H.L.E., Acevedo, N., Skallerup, P., Almeida, S., Skovgaard, K., Andresen, L., Skov, S., Caraballo, L., van Die, I., Jørgensen, C.B., Fredholm, M., Thamsborg, S.M., Nejsum, P.,* Williams, A.R.* (2018). Ascaris suum infection down-regulates mucosal inflammatory pathways in pigs in vivo and in human dendritic cells in vitro. Journal of Infectious Diseases, 218: 310-319 * shared senior author
  • Almeida, S., Nejsum, P., Williams, A.R. (2017). Modulation of human macrophage activity by Ascaris antigens is dependent on macrophage polarization state. Immunobiology, 223: 405-412
  • Hansen E.P., Kringel H., Williams A.R., Nejsum, P. (2015). Secretion of RNA-containing extracellular vesicles by the porcine whipworm, Trichuris suis. Journal of Parasitology, 101:336-340

CONTACT


Peter Nejsum

E-Mail: pn@clin.au.dk

Telephone: +45 50541392

Dep. Of Clinical Medicine
Dep. Of Infectious Diseases, Q-Research
Palle Juul-Jensens Boulevard 99
8200 Aarhus N
Denmark

CONTACTS


Scientific Contacts

Debora Berti

CSGI, Department of Chemistry University of Florence, via della Lastruccia 3, 50019 Florence (Italy)
berti@csgi.unifi.it

Paolo Bergese

CSGI, Department of Molecular and Translational Medicine, University of Brescia, Viale Europa 11, 25123 Brescia, Italy
paolo.bergese@unibs.it

Administrative Staff

Daniela Vullo

CSGI, Department of Chemistry University of Florence, via della Lastruccia 3, 50019 Florence (Italy)
evfoundry@csgi.unifi.it

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evFOUNDRY has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 801367