The group is part of Clinical Medicine at Aarhus University, and is based at the Department of Infectious Diseases at Aarhus University Hospital. The department has years of experience with the interplay between pathogens and the immune system, which is combined with a network branching beyond borders creating a great international expertise system and papers in high impact journals.
The group explore how products from parasitic worms (helminths) modulate the host immune response with a special focus on the role of extracellular vesicles (EVs). We search to determine the characteristics and role of EVs in the interplay between helminths and the host with the purpose of identifying novel therapeutics for autoimmune diseases and vaccines.
For the evFOUNDRY, our group will isolate and enrich for EVs from the porcine helminth Ascaris suum in the most efficient and optimal way. We also explore the characteristics and physical properties of EVs. Finally, we investigate the functionality of helminth-derived EVs using in vitro studies. In this way we will identify the best method, called ‘gold standard’ for Ascaris EV enrichment and compare that to the performance of the evFOUNDRY.
Telephone: +45 50541392
Dep. Of Clinical Medicine Dep. Of Infectious Diseases, Q-Research Palle Juul-Jensens Boulevard 99 8200 Aarhus N Denmark
CSGI, Department of Chemistry University of Florence,
via della Lastruccia 3, 50019 Florence (Italy)
CSGI, Department of Molecular and Translational Medicine, University of Brescia, Viale Europa 11, 25123 Brescia, Italy
CSGI, Department of Chemistry University of Florence, via della Lastruccia 3, 50019 Florence (Italy)
evFOUNDRY has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 801367